We have therefore researched in the development of this product, a variety of Rhodiola that would contain in their roots, active principles of high vibratory quality in order to augment its assimilation, its efficiency and rapidity of action.
Lapis Ostra, is an exclusive formula of extractions of eukaryote cells contained in the roots of Rhodiola Imbricata originally found in the Trans-Himalayan chain where it grows principally around 1600 and 4000 meters.
This variety of Rhodiola has a strong vitality and a high environmental capacity of adaptation: the genome sequences extracted from the eukaryotes, have a direct information action on the fabrication of the mitochondrial ATP (adenosine triphosphate) for our cells.
This extract contains the traditionally recognized active principles in the different varieties of Rhodiola.
The study of the phytochemistry of the root of R. Imbricata, revealed the presence of six distinct groups of chemical compounds :
1. Phenylpropanoids: rosavine, rosin (colophony) rosarine
2. Derivatives of the phenylethanol: salidroside (rhodioloside also known as phytosterol), tyrosol;
3. Flavanoids: rodioline, rodionine, rodiosine, acetylrodalginine, tricine;
4. Monoterpernes: rosiridol, rosaridine;
5. Triterpenes: daucosterol, beta-sitosterol;
6. Phenolic Acids: Chlorogenic Acids, Hydroxycinnamic Acids, Gallic Acids.
But equally, the presence of nine essential amino acids and twelve Non-essential amino acids were also quantified.
There is a total of 21 amino acids, of which 9 essential amino acids and 12 Non-essential amino acids :
1. L- Arginine (A) is Semi-essential
2. L- Aspartic Acid (D) is Non-essential
3. L- Glutamine Acid (Q) is Semi-essential
4. L- Serine (S) is Non-essential
5. L- Glycine (G) is Semi-essential
6. L- Histidine (H) is Essential
7. L- Threonine (T) is Essential
8. L- Alanine (A) is Non-essential
9. L- Proline (P) is Semi-essential
10. L- Methionine (M) is Essential
11. L- Cysteine (C) is Semi-essential
12. L- Selenocysteine (U) is Non-essential
13. L- Isoleucine (I) is Essential
14. L- Leucine (L) is Essential
15. L -Tyrosine (Y) is Semi-essential
16. L- Phenylalanine (F) is Essential
17. L- Lysine (K) is Essential
18. L- Asparagine (N) is Non-essential
19. L- Valine (V) is Essential
20. L- Tryptophan (W) is Essential
21. L- Glutamic Acid (E) is Non-essential
22. L- Ornithine is one of the products of the action of the enzyme arginase on l-arginine, creating urea
Amino acids are organic groups : twenty amino acids are building proteins and they are anchored in our genome. These twenty amino acids are considered as the basic amino acids. They are regrouped in three categories: the essential amino acids, the semi-essential amino acids also called conditionally essential amino-acids, and the non-essential amino acids.
Nine amino acids are essential to the human being. They are called essentials because the human organism cannot fabricate them and therefore the organism needs an external source of supply for his survival. They are isoleucine, leucine, lysine, methionine, phenylalanine, threonine, le tryptophan and valine. Certain of them l-Asparagine (N), l-Tryptophan (W) and l-Ornithine, are at the inferior limit of detection and their quantity has not been quantified.
The total lipid revealed itself to be a rich source in saturated fatty acids such as: decanoic acid (also known as capric acid, caproic acid (also known as hexanoic acid), palmitic acid, lignoceric acid and behenic acid (also known as docosanoic acid); together, they constituted 52% of the tenure in lipids (fat). The linoleic acid, the oleic acid, the arachidonic acid, the linolelaidic acid, the docosadienoic acid, are important unsaturated fatty acids (UFA). The mono unsaturated fatty acids (MUFA) and the polyunsaturated fatty acids represented respectively 35,64% and 12,33% of the tenure of lipids at the time of measurements.
The Rhodolia Impricata contain certain bioactive metabolites such as mineral ions and other secondary bioactive metabolites that will behave like osmolytes*, regulating the transport of ions**, stomatic modulating opening, etc., the detoxification of heavy metals, the modification of the fluidity of membranes, the synthesis and the activity of certain enzymes, the expression of genes and the homeostasis.
* The osmolytes are small molecules made of organic matter. They are soluble in the intracellular solution and play a role in the fight against stress related to the environment. In numerous cases, environmental stress threatens the organite stability of the proteins.
** The transports of ions or membranous transport corresponds to the passage of one ion through a plasma membrane. The metallic ions have a vibratory action pertaining to the opening or the closing of the intra/extra cellular activity.
These mineral ions are also essential micronutrients. They are necessary to maintain good health and a good vibration level. It has been discovered that the Rhodiola Imbricata contained thirteen essential mineral elements: calcium, potassium, iron, magnesium, phosphor, sodium, manganese, zinc, chrome, nickel, copper, cobalt and molybdenum. It must be noted that Rhodiola Imbricata contains altogether, calcium, magnesium and phosphor.
Amongst these mineral, we also find superoxide dismutase enzymes (SOD) that are metalloproteins. This enzyme intervenes in the oxidative explosion, and is equally an essential component of the elimination mechanism of free radicals.
The Rhodiola Imbricata is composed of rosavin, salidroside (also known as Rhodioloside), flavonoids, multiple amino acids, multiple assimilable minerals (vegetalized). Its antioxidant properties and anti-free radicals are powerful and it has an effective action in the regeneration of the skin process. Lapis Ostra made out of root extracts, activates the production of five neuro-transmitter molecules :
is an organic compound that plays the role of an adrenergic hormone and of a neurotransmitter. It is a catecholamine like dopamine or adrenaline.
It is principally liberated at the level of the cerebral trunk and by the nervous fibers of the orthosympathetic (or sympathetic) systems and plays the role of a neurotransmitter. Therefore, it plays a role in the excitation process, the orientation of new stimuli, the selective attention, vigilance, emotions, the wake and sleep process, dreaming, nightmares, the learning process and the reinforcement of certain memory circuits.
The sympathetic nervous system operates on a two neurons model: the preganglionic neuron (localized in the spinal cord), and one post-ganglionic neuron (localized in a ganglion). The preganglionic neuron is acetyl cholinergic, the post-ganglionic neuron is noradrenergic: they find themselves at the level of the Central Nervous System (CNS) and of the Peripheral Nervous System (PNS). The liberation of the noradrenaline by these neurons is accompanied with co-mediators, of the ATP function (adenosine triphosphate) and of neuropeptides.
The noradrenaline is secreted at the level of the medulla suprarenal glands that are responsible of the discharge of adrenaline, created by stress, conscious or unconscious, or following emotional or mental shocks.
Noradrenaline and adrenaline are produced and liberated in synaptic liaisons to act as neurotransmitters: they can be synthesized by the chromaffin cells, by the medulla suprarenal glands in order to act as hormones.
The efficiency of the organic compounds (amino acids) of the Rhodiola Imbricata, have an impact on the Central Nervous System (CNS).
The regulation of the medulla suprarenal glands allows to re-stimulate the excitation process, the attention, the emotions and to regulate wake and sleep, dreams and nightmares.
The amino acids and the metallic ions contained in the Lapis Ostra, maintain memory by permitting an adaptation to the chronic stress. As a matter of fact, it is recognized that the Rhodiola Imbricata is adaptogen, neuro-protective, cardio-protective, anti-fatigue, anti-depressor, anxiolytic, nootropic, augments the lifespan by the regulation of the Central Nervous System (CNS).
Serotonin [or 5-hydroxytryptamine (5-HT)] is a monoamine. It is a neurotransmitter of the Central Nervous System and it is equally present in the digestive tube (95% of the serotonin of the body) and it is produced in the intestine, as well as an autacoid (local hormone) liberated by the enterochromaffin cells and the thrombocytes.
The action of Rhodiola Imbricata by its amino acids, its fatty acids and its metalloids, provoke a liberation of the serotonin which is implicated in the management of moods and happiness. When at high level, serotonin reduces the risk taking. It is antagonistic to dopamine (start/stop). It is implicated in the regulation of the Circadian cycle (biological clock) but also in the digestive system and in diverse troubles like stress, anxiety, phobia and depressions. Serotonin is also implicated in the transmission and the control of pain.
Dopamine (DA) is a precursor neurotransmitter of the noradrenalin and the adrenalin that allows the communication within the nervous system: it has a direct influence on the behavior, and most particularly on the sensation of pleasure and of the sense of action, which is the case when in depression.
It is indispensable to survival: it is the product of two amino acids: tyrosine or phenylalanine. It influences the functions of two receptors located at the postsynaptic and presynaptic levels but it also plays an essential role in the motor and psychic functions.
People with a high level of dopamine have generally a higher tendency to be risk takers. It is therefore interesting to note that Lapis Ostra is lightly anxiolytic, and has an action on the dopamine.
And more, dopamine inhibits the liberation of prolactin which is a peptide hormone derived from amino acids and fatty based hormones. It has multiple roles, it intervenes notably in lactation, reproduction, libido, growth, immunity and behavior.
Acetylcholine (ACh) is a neurotransmitter that plays an essential role in the Central Nervous System (CNS) influencing memory, the cardiac rhythm of the heart, the blood vessels for the control of the arterial pressure and the vasodilatation, the lungs for the contraction of the bronchial tubes and the expectoration of secretions, the intestines and the stomach for the contraction and the secretions of the gastric juices, the salivary glands and the saliva, the eyes and their lachrymal liquid and the contraction of the pupil, the medulla suprarenal glands for the orthosympathetic system, and for the contractions of the muscles.
Acetylcholine acts at the level of the Central Nervous System (CNS) and in numerous other functions like the regulation of the motor control, if perturbed for example in the case of the Parkinson, or of the memory perturbed by the Alzheimer.
It is most probable that Lapis Ostra, due to the presence of certain amino acids and other biochemical compounds, even in infinitesimal doses, could impede the degradation of the level of acetylcholine.
Acetylcholine fixes itself to the surface of the receptors of the postsynaptic neurons that are principally of two types: the nicotinic (sympathetic and parasympathetic) and the muscarinic (parasympathetic target).
The sympathetic and parasympathetic systems are the autonomous nervous system (or vegetative) that regulates all the body process that happen automatically, like the blood flow (heart beat and arterial pressure), respiration, digestion, the maintenance of the body temperature, transpiration, etc…
The extracts from Rhodiola Imbricata have an anti-fatigue effect by their cognitive actions on the brain (corpus callosum) and on the Central Nervous System (CNS), and also on the epiphysis and the pituitary gland (the hypophysis), that permits the regulation of the norepinephrine and also the medulla suprarenal glands which leads to the regulation of the mental most particularly the skill of concentration in patients suffering from a burn out following a syndrome of fatigue or chronic exhaustion caused by emotional or mental post-traumatic shocks or by the condition of a difficult life. The active principle of the Rhodiola prevents the degradation of the serotonin, the dopamine and the catecholamines of the brain.
Lapis Ostra is adaptogen and reduces the damages caused by stress factors by modifying the reactivity of the system of the organism, including the hypothalamic axis of the hypophysis (HPA) and of the Sympatico adrenal system. Moreover, it has a regulator action on the adrenocorticotropic hormone (ACTH) and other biologically active substances (β-endorphin). ACTH stimulates the synthesis of the cortisol, the glucocorticoids, the mineral corticoids and of the DHEA (dihydroepiandrosterone has a very important role in the case of multiple sclerosis and of the amyotrophic lateral sclerosis).
The extracts of eukaryotic “active” cells from this root, also have a positive action on the digestive system and the heavy metals. They protect the liver against the chemical toxins coming out of the diet or the medications. They have a preventive action against certain forms of cellular degeneration (cancers) by a re-initialization action (on telomeres), regulates the kidneys and the prostate, the irritable bowel syndrome: spasmodic trouble of the intestines and equally renal troubles (renal colic).
These extracts also have an action on cardiac troubles: hypertension, blood flow regulation, regularization of the cardiac rhythm (arrhythmia), and is a cardio protector and protects against anti-spasmophilia.
They also act against the stress, asthenia, depression, affectivity problems, overworking, fibromyalgia, nervous equilibrium, articular pain due to fatigue, on sexuality and libido; they prevent the infections, the amenorrhea, infertility and sexual dysfunctions.
Lapis Ostra has a regulating action on the mood, the anxiety, on emotions, on the amygdala, the hippocampus, the hypothalamus, and the middle brain. It stimulates the cholinergic nicotinic activity in the emotional circuits of the limbic system (in the temporal lobe). The alterations of the levels of monoamines neuro-transmitters (derived from amino acids) will provoke a complex spectrum of psychotropic activities.
By the regulation of the Central Nervous System (CNS) along with the sympathetic and parasympathetic, these extracts have an action on Parkinson disease and the Alzheimer disease.
At the sanguine level, these extracts have a light anti-coagulant action because they re-oxygenate the blood and regulate menstruations. They favor the regulation of glycaemia (diabetes) by acting on the insulin level by re-equilibrating the hypoxia of the pancreas.
Its anti-oxidant properties are powerful and confer an efficient action to combat the aging of the skin.
• better oxygenation of the brain and of the blood
• development of the cognitive functions (improves the information process between the left brain and the right brain
• maintains the physical bio-regulation of the hormonal functions
• bio-regulative action on the epiphysis and hypophysis
• action on the telomere
• action on the Central Nervous System (CNS)
• anti-stress and bio-regulation action of the production functions of the adrenaline and the noradrenaline
• improves the physical effort and its recuperation after physical exercise by the bringing-in of oxygen in the muscles
• improves the quality of sleep (bio-regulation of the melatonin level)
• bio-regulation of the cardiovascular functions and of the sexuality (non vasodilator)
• promotes the natural production of the DHEA (dehydroepiandrosterone)
This extract contains four essential amino acids, in infinitesimal doses, regenerators of the organism and its telomerase function (epithalamin).
No secondary effects have been observed, nor any intolerance with other therapeutic products.
It has been observed within many military research departments, that many varieties of Rhodiola had strong qualities for cellular protection.
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